千葉大学大学院理学研究科附属 膜タンパク質研究センター

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研究成果

論文

  1. Taisei Yamamoto, Satoshi Yasuda, Rinshi S. Kasai, Ryosuke Nakano, Simon Hikiri, Kanna Sugaya, Tomohiko Hayashi, Satoshi Ogasawara, Mitsunori Shiroishi, Takahiro K. Fujiwara, Masahiro Kinoshita, Takeshi Murata
    "A methodology for creating mutants of G-protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering"
    Protein Sci., 31, e4425 (2022).

  2. Kanna Sugaya, Satoshi Yasuda, Shingo Sato, Chen Sisi, Taisei Yamamoto, Daisuke Umeno, Tomoaki Matsuura, Tomohiko Hayashi, Satoshi Ogasawara, Masahiro Kinoshita, Takeshi Murata
    "A methodology for creating thermostabilized mutants of G-protein coupled receptors by combining statistical thermodynamics and evolutionary molecular engineering"
    Protein Sci., 31, e4404 (2022).

  3. Arif Md. Rashedul Kabir, Tasrina Munmun, Tomohiko Hayashi, Satoshi Yasuda, Atsushi P. Kimura, Masahiro Kinoshita, Takeshi Murata, Kazuki Sada, and Akira Kakugo
    "Controlling the Rigidity of Kinesin-Propelled Microtubules in an In Vitro Gliding Assay Using the Deep-Sea Osmolyte Trimethylamine N-Oxide"
    CS Omega, 7, 3796-3803 (2022).

  4. Satoshi Yasuda, Tomoki Akiyama, Keiichi Kojima, Tetsuya Ueta, Tomohiko Hayashi, Satoshi Ogasawara, Satoru Nagatoishi, Kouhei Tsumoto, Naoki Kunishima, Yuki Sudo, *Masahiro Kinoshita, and *Takeshi Murata
    "Development of an Outward Proton Pumping Rhodopsin with a New Record in Thermostability by Means of Amino Acid Mutations"
    J. Phys. Chem. B,(2022) doi: https://doi.org/10.1021/acs.jpcb.1c08684.

  5. Takeshi Haraguchi, Masanori Tamanaha, Kano Suzuki, Kohei Yoshimura, Takuma Imi, Motoki Tominaga, Hidetoshi Sakayama, Tomoaki Nishiyama, Takeshi Murata, and Kohji Ito
    "Discovery of ultrafast myosin, its amino acid sequence, and structural features"
    Proc. Natl. Acad. Sci. USA,(2022) doi: https://doi.org/10.1073/pnas.2120962119.

プレスリリース

  1. "最も安定な水素イオン排出ポンプの創出に成功 理論計算を駆使して膜タンパク質を効率的かつ大幅に耐熱化する手法を構築"
    令和4年2月21日

  2. "生物界で最速のミオシンの発見とその構造解析に成功 植物の成長促進やナノマシン開発に期待"
    令和4年2月21日

新聞掲載

  1. "ミオシン、生物界最速 モータータンパク超高速運動ナノマシンに道"
    日刊工業新聞、令和4年3月1日
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