▶ 結晶構造


THE MEMBRANE ROTOR OF THE V-TYPE ATPASE FROM ENTEROCOCCUS HIRAE [PDB ID : 2BL2]

Takeshi Murata, Ichiro Yamato, Yoshimi Kakinuma *Andrew G. W. Leslie and *John E. Walker (2005) Structure of the rotor of the V-type Na+-ATPase from Enterococcus hirae. ; Science 308, 654-659

Science 308 (#5722, 29 April 2005) の表紙に選ばれた。

Crystal structure of Lithium bound rotor ring of the V-ATPase from Enterococcus hirae [PDB ID : 2CYD]

*Takeshi Murata, Ichiro Yamato, Yoshimi Kakinuma, Mikako Shirouzu, John E. Walker, Shigeyuki Yokoyama, and So Iwata (2008) Ion binding and selectivity of the rotor ring of the Na+-transporting V-ATPase; Proc. Natl. Acad. Sci. U. S. A., 105, 8607-8612

Crystal structure of nitric oxide reductase from Pseudomonas aeruginosa in complex with antibody fragment [PDB ID : 3O0R]

Tomoya Hino, Yushi Matsumoto, Shingo Nagano, Hiroshi Sugimoto, Yoshihiro Fukumori, Takeshi Murata, So Iwata and *Yoshitsugu Shiro (2010) Structural Basis of Biological N2O Generation by Bacterial Nitric Oxide Reductase; Science, 330, 1666-1670

※ 理化学研究所 城生体金属科学研究室との共同研究による。

Crystal structure of rotor ring with DCCD of the V- ATPase from Enterococcus hirae [PDB ID : 2DB4]
Structure of the Na+ unbound rotor ring modified with N,N f-Dicyclohexylcarbodiimide of the Na+-transporting V-ATPase [PDB ID : 3AOU]

Kenji Mizutani, Misaki Yamamoto, Kano Suzuki, Ichiro Yamato, Yoshimi Kakinuma, Mikako Shirouzu, John E Walker, Shigeyuki Yokoyama, So Iwata, and *Takeshi Murata (2011) Structure of the rotor ring modified with N,N'-dicyclohexylcarbodiimide of the Na+-transporting vacuolar ATPase; Proc. Natl. Acad. Sci. U. S. A., 108, 13474-13479

Crystal structure of the central axis (NtpD-NtpG) in the catalytic portion of Enterococcus hirae V-type sodium ATPase [PDB ID : 3AON]

Shinya Saijo, Satoshi Arai, Khandoker M. M. Hossain, Kano Suzuki, Ichiro Yamato, Yoshimi Kakinuma, Yoshiko Ishizuka-Katsura, Noboru, Ohsawa, Takaho Terada, Mikako Shirouzu, Shigeyuki Yokoyama, So Iwata, and *Takeshi Murata (2011) Crystal structure of the central axis DF complex of the prokaryotic V-ATPase; Proc. Natl. Acad. Sci. U. S. A., 108, 19955-19960

Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 2.7 A resolution [PDB ID : 3VG9]
Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 3.1 A resolution [PDB ID : 3VGA]

Tomoya Hino, Takatoshi Arakawa, Hiroko Iwanari, Takami Yurugi-Kobayashi, Chiyo Ikeda-Suno, Yoshiko Nakada-Nakura, Osamu Kusano-Arai, Simone Weyand, Tatsuro Shimamura, Norimichi Nomura, Alexander D. Cameron, Takuya Kobayashi, Takao Hamakubo, *So Iwata and *Takeshi Murata (2012) G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody; Nature, 482, 237-240

Crystal structure of nucleotide-free A3B3 complex from Enterococcus hirae V-ATPase [PDB ID : 3vr2]
Crystal structure of AMP-PNP bound A3B3 complex from Enterococcus hirae V-ATPase [PDB ID : 3vr3]
Crystal structure of Enterococcus hirae V1-ATPase [PDB ID : 3vr4]
Crystal structure of nucleotide-free Enterococcus hirae V1-ATPase [PDB ID : 3vr5]
Crystal structure of AMP-PNP bound Enterococcus hirae V1-ATPase [PDB ID : 3vr6]

Satoshi Arai, Shinya Saijo, Kano Suzuki, Kenji Mizutani, Yoshimi Kakinuma, Yoshiko Ishizuka-Katsura, Noboru Ohsawa, Takaho Terada, Mikako Shirouzu, Shigeyuki Yokoyama, So Iwata, Ichiro Yamato and *Takeshi Murata (2013) Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures; Nature, 493, 703-707

Crystal structure of the human adiponectin receptor 1 [PDB ID : 3WXV]
Crystal structure of the human adiponectin receptor 2 [PDB ID : 3WXW]

Hiroaki Tanabe, Yoshifumi Fujii, Miki Okada-Iwabu, Masato Iwabu, Yoshihiro Nakamura, Toshiaki Hosaka, Kanna Motoyama, Mariko Ikeda, Motoaki Wakiyama, Takaho Terada, Noboru Ohsawa, Masakatsu Hato, Satoshi Ogasawara, Tomoya Hino, Takeshi Murata, So Iwata, Kunio Hirata, Yoshiaki Kawano, Masaki Yamamoto, Tomomi Kimura-Someya, Mikako Shirouzu, Toshimasa Yamauchi, Takashi Kadowaki and Shigeyuki Yokoyama (2015) Crystal structures of the human adiponectin receptors; Nature, 520, 312-316

※ 理化学研究所 横山研究室、東京大学大学院医学系研究科 門脇研究室、京都大学大学院医学研究科 岩田研究室との共同研究による。

Rat GLUT5 with Fv in the outward-open form [PDB ID : 4YBQ]

*Norimichi Nomura, Gregory Verdon, Hae Joo Kang, Tatsuro Shimamura, Yayoi Nomura, Yo Sonoda, Saba Abdul Hussien, Aziz Abdul Qureshi, Mathieu Coincon, Yumi Sato, Hitomi Abe, Yoshiko Nakada-Nakura, Tomoya Hino, Takatoshi Arakawa, Osamu Kusano-Arai, Hiroko Iwanari, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, Michihiro Kasahara, *So Iwata, *David Drew (2015) Structure and mechanism of the mammalian fructose transporter GLUT5; Nature, 526, 397-401

※ 京都大学大学院医学研究科 岩田研究室との共同研究による。

Crystal structure of the anion exchanger domain of human erythrocyte Band 3 [PDB ID : 4YZF]

Takatoshi Arakawa, Takami Kobayashi-Yugiri, Yilmaz Alguel, Hiroko Iwanari, Hinako Hatae, Momi Iwata, Tomoya Hino, Chiyo, Ikeda-Suno, Hiroyuki Kuma, Yoshito Abe, Dongchon Kang, Takeshi Murata, Takao Hamakubo, *Alexander Cameron, *Takuya Kobayashi, *Naotaka Hamasaki and *So Iwata (2015) Crystal structure of the anion exchanger domain of human erythrocyte band 3; Science, 350, 680-684

※ 京都大学大学院医学研究科 岩田研究室、長崎国際大学薬学部 濱崎研究室との共同研究による。

Crystal structure of the 2 ADP-bound V1 complex. [PDB ID : 5KNB]

Crystal structure of the 3 ADP-bound V1 complex. [PDB ID : 5KNC]

Crystal structure of the Pi-bound V1 complex. [PDB ID : 5KND]

Kano Suzuki, Kenji Mizutani, Shintaro Maruyama, Kazumi Shimono, Fabiana L. Imai, Eiro Muneyuki, Yoshimi Kakinuma, Yoshiko Ishizuka-Katsura, Mikako Shirouzu, Shigeyuki Yokoyama, Ichiro Yamato, and *Takeshi Murata (2016) Crystal structures of the ATP-binding and ADP-release dwells of the V1 rotary motor; Nat. Commun., 7, 13235

※ 東邦大学薬学部薬物動態学教室、中央大学理工学部宗行研究室、愛媛大学農学部柿沼研究室、理化学研究所ライフサイエンス技術基盤研究センター及び、横山研究室との共同研究による。

Crystal structure of thermophilic rhodopsin [PDB ID : 5AZD]

Takashi Tsukamoto, Kenji Mizutani, Taisuke Hasegawa, Megumi Takahashi, Naoya Honda, Naoki Hashimoto, Kazumi Shimono, Keitaro Yamashita, Masaki Yamamoto, Seiji Miyauchi, Shin Takagi, Shigehiko Hayashi, *Takeshi Murata and *Yuki Sudo (2016) "X-ray Crystallographic Structure of Thermophilic Rhodopsin: Implications for High Thermal Stability and Optogenetic Function; J. Biol. Chem., 291, 12223-12232

※ 岡山大学大学院医歯薬学総合研究科 須藤研究室との共同研究による。

Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with AF-DX 384. [PDB ID : 5ZKB]

*Ryoji Suno, Sangbae Lee, Shoji Maeda, Satoshi Yasuda, Keitaro Yamashita, Kunio Hirata, Shoichiro Horita, Maki S. Tawaramoto, Hirokazu Tsujimoto, Takeshi Murata, Masahiro Kinoshita, Nagarajan Vaidehi, Masaki Yamamoto, Brian K Kobilka, Nagarajan Vaidehi, So Iwata, *Takuya Kobayashi (2018) Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor; Nat. Chem. Biol., 14, 1150-1158

※ 京都大学大学院医学研究科 岩田研究室らとの共同研究による。

Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and ONO-AE3-208 [PDB ID : 5YWY]

Yosuke Toyoda, Kazushi Morimoto, Ryoji Suno, Shoichiro Horita, Keitaro Yamashita, Kunio Hirata, Yusuke Sekiguchi, Satoshi Yasuda, Mitsunori Shiroishi, Tomoko Shimizu, Yuji Urushibata, Yuta Kajiwara, Tomoaki Inazumi, Yunhon Hotta, Hidetsugu Asada, Takanori Nakane, Yuki Shiimura, Tomoya Nakagita, Kyoshiro Tsuge, Suguru Yoshida, Tomoko Kuribara, Takamitsu Hosoya, Yukihiko Sugimoto, Norimichi Nomura, Miwa Sato, Takatsugu Hirokawa, Masahiro Kinoshita, Takeshi Murata, Kiyoshi Takayama, Masaki Yamamoto, *Shuh Narumiya, *So Iwata, and *Takuya Kobayashi (2019) "Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface"; Nat. Chem. Biol., 15, 18-26 (2019).

※ 京都大学大学院医学研究科 岩田研究室らとの共同研究による。

Crystal structure of the nucleotide-free mutant A3B3. [PDB ID : 5ZEA]

Crystal structure of AMP-PNP bound mutant A3B3 complex from Enterococcus hirae V-ATPase. [PDB ID : 5ZE9]

Shintaro Maruyama, Kano Suzuki, Motonori Imamura, Hikaru Sasaki, Hideyuki Matsunami, Kenji Mizutani, Yasuko Saito, Fabiana L. Imai, Yoshiko Ishizuka-Katsura Tomomi Kimura-Someya, Mikako Shirouzu, Takayuki Uchihashi, Toshio Ando, Ichiro Yamato, and *Takeshi Murata (2019) "Metastable asymmetrical structure of a shaftless V1 motor"; Sci. Adv., 5, eaau8149

※ 金沢大学ナノ生命科学研究所、理化学研究所生命機能科学研究センター、東京理科大学基礎工学部生物工学科山登研究室、名古屋大学大学院理学研究科内橋研究室との共同研究による。

Crystal structure of thermophilic rhodopsin from Rubrobacter xylanophilus [PDB ID : 6KFQ]

Tomohiko Hayashi, Satoshi Yasuda, Kano Suzuki, Tomoki Akiyama, Kanae Kanehara, Keiichi Kojima, Mikio Tanabe, Ryuichi Kato, Toshiya Senda, Yuki Sudo, *Takeshi Murata, and *Masahiro Kinoshita (2019) "How Does a Microbial Rhodopsin RxR Realize Its Exceptionally High Thermostability with the Proton-Pumping Function Being Retained?"; J. Phy. Chem. B, 124, 990-1000 (2020).

※ 岡山大学大学院医歯薬学総合研究科 須藤研究室との共同研究による。